James E Cassat Selected Research

Diflunisal (Dolobid)

1/2021	Diflunisal-loaded poly(propylene sulfide) nanoparticles decrease S. aureus-mediated bone destruction during osteomyelitis.
1/2020	Concurrent Local Delivery of Diflunisal Limits Bone Destruction but Fails To Improve Systemic Vancomycin Efficacy during Staphylococcus aureus Osteomyelitis.
1/2016	Repurposing the Nonsteroidal Anti-inflammatory Drug Diflunisal as an Osteoprotective, Antivirulence Therapy for Staphylococcus aureus Osteomyelitis.

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James E Cassat Research Topics

Disease

13	Infections 01/2022 - 05/2013
10	Osteomyelitis 01/2021 - 06/2013
4	Staphylococcal Infections 01/2021 - 03/2012
3	Abscess 03/2021 - 10/2013
1	Colitis 01/2022
1	Inflammation (Inflammations) 01/2022
1	Cross Infection (Nosocomial Infection) 01/2020
1	Neoplasms (Cancer) 01/2018
1	Breast Neoplasms (Breast Cancer) 01/2018
1	Sepsis (Septicemia) 09/2002

Drug/Important Bio-Agent (IBA)

7	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 09/2002
5	Pharmaceutical PreparationsIBA 01/2021 - 01/2016
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 10/2013
3	Diflunisal (Dolobid)FDA Link 01/2021 - 01/2016
3	Virulence Factors (Pathogenicity Factors)IBA 01/2021 - 10/2013
2	Monoclonal AntibodiesIBA 01/2022 - 01/2017
2	CytokinesIBA 01/2022 - 01/2018
2	IronIBA 07/2013 - 05/2013
1	lysylphosphatidylglycerolIBA 01/2022
1	Capsules (Microcapsules)IBA 03/2021
1	FibrinIBA 03/2021
1	CollagenIBA 03/2021
1	poly(propylene sulfide)IBA 01/2021
1	PolyestersIBA 01/2020
1	Aspartic Acid (Aspartate)FDA Link 01/2020
1	Urethane (Ethyl Carbamate)IBA 01/2020
1	Vancomycin FDA LinkGeneric 01/2020
1	Neutralizing AntibodiesIBA 01/2018
1	leukotoxinIBA 01/2017
1	Anti-Infective Agents (Microbicides)IBA 01/2017
1	EpitopesIBA 01/2017
1	Phenol (Carbolic Acid)FDA Link 01/2016
1	ProteomeIBA 10/2013
1	Histones (Histone)IBA 10/2013
1	Heme (Haem)IBA 07/2013
1	Oxidoreductases (Dehydrogenase)IBA 07/2013
1	Peptide Hydrolases (Proteases)FDA Link 06/2013
1	MetalsIBA 03/2012

Therapy/Procedure

8	Therapeutics 01/2021 - 09/2002
3	Debridement 12/2020 - 01/2017
1	Operative Surgical Procedures 01/2019
1	Orthopedic Procedures 01/2017